Abstract:
Background & Objective: Bacterial infections are the major cause of acute exacerbation
of COPD (AE-COPD). The natural history of chronic obstructive pulmonary disease is
characterized by frequent exacerbations. Majority of exacerbations are infectious and bacteria
responsible for 30-50% of these cases. Appropriate use of antibiotic reduce mortality, hospital
stay, subsequent exacerbations, further lung damage and also prevention of development of
antibiotic resistance.

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